Anti-GABA-A-R-Beta2/3 Antibody 75-363 from Antibodies Inc.

Product Specs
ItemAnti-GABA-A-R-Beta2/3 Antibody
CompanyAntibodies Inc.
Price Pricing Info Supplier Page View Company Product Page
Catalog Number75-363
Antibody TypePrimary Antibody
ClonalityMonoclonal
ReactivityBovine, Chicken, Human, Mouse, and Rat
Regulatory StatusThese antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans
FormatLiquid, Purified by Protein A chromatography
ApplicationsEM, IHC, ICC, IP, WB
Clone62-3G1
Gene NameGABRB3
HostMouse
Quantity100 µL
Molecular Weight55 kDa
TargetGABA-A-R-Beta2/3
IsotypeIgG1
Conjugate/TagUnconjugated
Brand/TrademarkNeuroMab
ImmunogenFraction of bovine brain GABA-A receptor affinity purified against immobilized benzodiazepine Ro7-1986/1 (1988 de Blas et al J Neurosci PMID 2828565, 1988 Vitorica et al J Neurosci PMID 2828566). Target initially identified as a GABA-A receptor by: 1). rat brain immunocytochemistry staining pattern via light microscopy identical to that seen via ligand autoradiography with 3H-muscimol; 2). immunoprecipitation of 3H-muscimol-binding activity of the purified receptor complex; 3). recognition of ~57 kDa protein in immunoblots against crude rat brain membrane fractions Binding epitope identified to be within amino acids 26-40 (QSVNDPGNMSFVKET, extracellular N-terminus, 1992 Ewert et al Brain Res, PMID 1377081) of human GABA-A-R-Beta3 (also known as Gamma-aminobutyric acid receptor subunit beta-3, accession number P28472)
ValidationEach new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band
NCBI Gene AliasesDEE43, ECA5, EIEE43